Increase Text Size Reduce Text Size Print This Page E-mail This Page

Evoxac Can Help

EVOXAC side effects

Everyone responds to prescription medicine differently. This is also the case with EVOXAC^® (cevimeline HCl). That’s why it’s important that you talk with your doctor about any concerns you have when you start a new medicine.

Possible side effects of EVOXAC

Some side effects you experience may be signs that EVOXAC is starting to work. For example, EVOXAC causes your sweat glands to increase their activity, so you may sweat more after starting EVOXAC. If this happens, you should drink extra water and tell your healthcare provider, as dehydration may develop.

Of the side effects experienced by at least 10% of the patients taking EVOXAC, the following were seen more often in patients who took EVOXAC than in patients who took placebo:

Side effects	EVOXAC	Placebo
Excessive sweating	18.7%	2.4%
Nausea (upset stomach)	13.8%	7.9%
Sinusitis (sinus infection)	12.3%	10.9%
Upper respiratory tract infection	11.4%	9.1%
Rhinitis (runny nose)	11.2%	5.4%

The following side effects were seen by at least 10% of patients taking EVOXAC but less often or equal than in patients taking placebo:

Side effects	EVOXAC	Placebo
Headache	14.4%	20.1%
Diarrhea	10.3%	10.3%

To learn more about side effects, be sure to read the Product Information and talk to your healthcare professional.

Tips for managing side effects of EVOXAC

You should tell your doctor about any side effects you have while taking EVOXAC. This way, you and your doctor can decide the best way to manage them.

Here are some tips to cope with common side effects:

Excessive sweating
- Drink extra water, especially in hot weather, so you don’t become dehydrated
- Use an antiperspirant that has 10%-15% aluminum chloride to help control underarm sweating
- Wear loose, natural-fiber clothing that lets sweat evaporate
- Avoid spicy foods and drinks with caffeine
Nausea (upset stomach)
- Stay hydrated by drinking small amounts of clear fluids often
- Eat smaller amounts of food more often. For example, try eating five smaller meals instead of three larger meals
- Don’t drink a lot with your meals. This may make your nausea worse
- Avoid foods that are spicy, greasy, or hot, as well as foods with strong smells

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Living with dry mouth

Questions for
your doctor

This interactive questionnaire can help you create a personalized list of questions for your doctor.

IMPORTANT SAFETY INFORMATION

What is EVOXAC?

EVOXAC (cevimeline HCl) is a prescription medicine used to treat symptoms of dry mouth in patients with Sjögren's syndrome.

Who Should Not Take EVOXAC?

You should not take EVOXAC if you have uncontrolled asthma, allergies to EVOXAC or a condition affecting the contraction of your pupil such as narrow-angle (angle-closure) glaucoma or inflammation of the iris.

What should I tell my Healthcare Provider?

Tell your healthcare provider if you have any of the following conditions:
- History of heart disease;
- Controlled asthma;
- Chronic bronchitis;
- Chronic obstructive pulmonary disease (COPD);
- History of kidney stones;
- History of gallbladder stones
Tell your healthcare provider if you are trying to become pregnant, are already pregnant, or are breastfeeding.
Tell your healthcare provider about all medications that you are taking, including those you take without a prescription. It is particularly important to tell your healthcare provider if you are taking any heart medications especially "beta-blockers".
If you are older than 65, your healthcare provider may want to monitor you more closely.

General Precautions with EVOXAC

When taking EVOXAC use caution when driving at night or performing other hazardous activities in reduced lighting because EVOXAC may cause blurred vision or changes in depth perception.
If you sweat excessively while taking EVOXAC drink extra water and tell your health care provider, as dehydration may develop.
The safety and effectiveness of EVOXAC in patients under 18 years of age have not been established.

What are some possible side effects of EVOXAC?

In clinical trials, the most commonly reported side effects were excessive sweating, headache, nausea, sinus infection, upper respiratory infections, runny nose, and diarrhea.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088.

For patients having difficulty affording their Daiichi Sankyo medication, please call the Daiichi Sankyo Patient Assistance Program at 1-866-268-7327 for more information or visit www.dsi.com/news/patientassistance.html

Please click here for full Product Information for EVOXAC.

The content provided herein is for informational purposes only and does not constitute or substitute for professional medical advice, diagnosis, or treatment. Talk to your doctor for more information about your specific condition.

Some photos in this site depict models, not actual patients or healthcare professionals.

This information is intended for U.S. residents only.