Order free samples of EVOXAC for your patients.
Important Safety Information
EVOXAC is indicated for the treatment of dry-mouth symptoms of Sjögren's syndrome.
Cevimeline HCI is contraindicated in patients with uncontrolled asthma, known hypersensitivity to the drug, and when miosis is undesirable, e.g., in acute iritis and narrow-angle (angle-closure) glaucoma
Cevimeline HCI can potentially alter cardiac conduction and heart rate and produce transient changes in hemodynamics. Cevimeline HCI should be administered with caution and under close medical supervision to patients with a history of cardiac disease, controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease
Cevimeline HCI should be administered with caution to patients taking beta-adrenergic antagonists because of the possibility of conduction disturbances and to patients with a history of nephrolithiasis or cholelithiasis
If a patient sweats excessively while taking cevimeline HCI, dehydration may develop
Caution should be advised while driving at night or performing hazardous activities in reduced lighting
Safety and effectiveness in pediatric patients have not been established
Cevimeline HCI is metabolized by the P-450 isozymes CYP2D6 and CYP3A3/4. Thus, there may be potential for interaction between cevimeline HCI and other compounds
Special care should be exercised when cevimeline HCI is taken by geriatric patients, considering the greater frequency of decreased hepatic, renal, or cardiac function
The most frequently reported adverse events associated with the pharmacologic action of a muscarinic agonist (>10% incidence) in clinical trials of cevimeline HCI were: excessive sweating, nausea, rhinitis, and diarrhea. Consult the full Prescribing Information for other adverse events
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